Developing treatment for adrenocortical carcinoma
نویسندگان
چکیده
منابع مشابه
Developing treatment for adrenocortical carcinoma.
Cancer of the adrenal cortex (ACC) is a rare endocrine malignancy with limited treatment options. Patients typically present with autonomous hormonal overproduction and/or a large abdominal mass. Hormonal assays and medical imaging can be diagnostic, but urinary steroid profiling might be a more sensitive technique to assess malignancy in adrenal tumours. The stage of the disease at diagnosis i...
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respond to metoclopramide, domperidone, ranitidine, amantadine, levodopa, carbamazepine, clonidine, prazosin, haloperidol, methysergide, or metoprolol. He improved slightly with the application of scopolamine patches, which had to be stopped because of side-effects. Intramuscular chlorpromazine (25 mg) would sometimes prevent attacks for up to a week. He was prescribed baclofen 10 mg, three tim...
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Adrenocortical carticnoma (ACC) is a rare malignancy with an incidence of 0.7-2.0 cases/million habitants/year. The diagnosis of malignancy relies on careful investigations of clinical, biological, and imaging features before surgery and pathological examination after tumor removal. Most patients present with steroid hormone excess or abdominal mass effects, but 15% of patients with ACC is init...
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Adrenocortical carcinoma is an uncommon and aggressivemalignancy. Despite a high frequency of metastasis, cutaneousmetastasis of adrenocortical carcinoma is rare with only isolatedcase reports. Its diagnosis can be challenging based solely onhistopathological findings. Yet, the clinical history in combinationwith an immunohistochemical panel consisting of inhibin,vimentin, chromogranin, synapto...
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Adrenocortical carcinoma (ACC) is an orphan malignancy that has attracted increasing attention during the last decade. Here we provide an update on advances in the field since our last review published in this journal in 2006. The Wnt/β-catenin pathway and IGF-2 signaling have been confirmed as frequently altered signaling pathways in ACC, but recent data suggest that they are probably not suff...
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ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2015
ISSN: 1351-0088,1479-6821
DOI: 10.1530/erc-15-0318